GDC-0084
A potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively; highly selective against a panel of 229 kinases (IC50>1 uM) ; shows antiproliferative (EC50 =0.3-1.1 uM) in 5 GBM cell lines; significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice.Brain Cancer Phase 2 Discontinued.
Product Specifications
CAS Number
1382979-44-3
Product Name Alternative
RG-7666
Purity
>98% (HPLC)
Solubility
DMSO: 6 mg/mL (Need ultrasonic)
Smiles
NC1=NC=C (C2=NC (N3CCOCC3) =C4N=C (C (C) (C) OCC5) N5C4=N2) C=N1
Molecular Formula
C18H22N8O2
Molecular Weight
382.4197
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Pyrimidinamine, 5-[8,9-dihydro-6,6-dimethyl-4- (4-morpholinyl) -6H-[1,4]oxazino[4,3-e]purin-2-yl]-
Available Sizes
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