Kenpaullone
Kenpaullone (9-Bromopaullone, NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM) ; shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM; displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.
Product Specifications
CAS Number
142273-20-9
Product Name Alternative
9-Bromopaullone | NSC-664704
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
O=C (NC1=CC=CC=C12) CC3=C2NC4=C3C=C (Br) C=C4
Molecular Formula
C16H11BrN2O
Molecular Weight
327.1754
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Indolo[3,2-d][1]benzazepin-6 (5H) -one, 9-bromo-7,12-dihydro-
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