CZ-415
A potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2; displays >100-fold selectivity over PI3Ks; inhibit downstream targets phosphorylation of pS6RP (S240/244) and pAkt (S473) in HEK293T cells with IC50 of 14.5 nM and 14.8 nM, inhibits IFNγ production in stimulated human whole blood with IC50 of 226 nM; shows efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.
Product Specifications
CAS Number
1429639-50-8
Product Name Alternative
CZ415
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
O=C (NCC) NC1=CC=C (C2=NC (N3[C@@H] (C) COCC3) =C4C (C (C) (C) S (C4) (=O) =O) =N2) C=C1
Molecular Formula
C22H29N5O4S
Molecular Weight
459.5618
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[ (3S) -3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
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