BLU9931
BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3 nM, shows much weaker activity for FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) and FGFR3 (IC50=150 nM) ; potently and selectively inhibits FGFR4 signaling and cell proliferation in HCC cell lines with an activated FGFR4 signaling pathway (Huh-7 cell IC50=110 nM, JHH-7 IC50=20 nM) ; shows remarkable antitumor activity in mice bearing HCC tumor xenograft that overexpresses FGF19.Lung Cancer Phase 1 Clinical.
Product Specifications
CAS Number
1538604-68-0
Product Name Alternative
BLU-9931
Purity
>98% (HPLC)
Solubility
DMSO: 17 mg/mL
Smiles
COC1=CC (OC) =C (Cl) C (=C1Cl) C1=CC2=CN=C (NC3=C (C) C=CC=C3NC (=O) C=C) N=C2C=C1
Molecular Formula
C26H22Cl2N4O3
Molecular Weight
509.3839
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, N-[2-[[6- (2,6-dichloro-3,5-dimethoxyphenyl) -2-quinazolinyl]amino]-3-methylphenyl]-
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