EPZ-011989
EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTs; demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.Blood Cancer Preclinical.
Product Specifications
CAS Number
1598383-40-4
Product Name Alternative
EPZ011989
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
O=C (NCC1=C (C) C=C (C) NC1=O) C2=CC (C#CCN3CCOCC3) =CC (N (CC) [C@H]4CC[C@H] (N (CCOC) C) CC4) =C2C
Molecular Formula
C35H51N5O4
Molecular Weight
605.8105
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[ (1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl) methyl]-3-[ethyl[trans-4-[ (2-methoxyethyl) methylamino]cyclohexyl]amino]-2-methyl-5-[3- (4-morpholinyl) -1-propyn-1-yl]-
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