Lazertinib
Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations; shows the beneficial for the NSCLC with brain metastasis.Lung Cancer Phase 2 Clinical.
Product Specifications
CAS Number
1903008-80-9
Product Name Alternative
YH 25448 | YH25448 | GNS-1480 | GNS1480
Purity
>98% (HPLC)
Solubility
Ethanol: Insoluble; Water: Insoluble; DMSO: 10 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
C=CC (NC1=CC (NC2=NC=CC (N3N=C (C4=CC=CC=C4) C (CN (C) C) =C3) =N2) =C (OC) C=C1N5CCOCC5) =O
Molecular Formula
C30H34N8O3
Molecular Weight
554.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-{5-[ (4-{4-[ (dimethylamino) methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl) amino]-4-methoxy-2- (morpholin-4-yl) phenyl}prop-2-enamide
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