Ketoprofen
Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. (In Vitro) :Ketoprofen inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) .Ketoprofen (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells. (In Vivo) :Ketoprofen (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%) .Ketoprofen (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS.
Product Specifications
CAS Number
22071-15-4
Product Name Alternative
2- (3-benzoylphenyl) propionic Acid | Ketoprofen | (RS) -Ketoprofen
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 51 mg/mL (200.56 mM) ; DMSO: 51 mg/mL (200.56 mM)
Smiles
CC (C1=CC=CC (C (C2=CC=CC=C2) =O) =C1) C (O) =O
Molecular Formula
C16H14O3
Molecular Weight
254.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (3-benzoylphenyl) propanoic acid
Available Sizes
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