SC-79
A unique specific Akt activator; binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol; induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.; augments neuronal survival in mouse model for ischemic strok.
Product Specifications
CAS Number
305834-79-1
Product Name Alternative
SC79
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC1=C (C (OCC) =O) C (C (C (OCC) =O) C#N) C2=CC (Cl) =CC=C2O1
Molecular Formula
C17H17ClN2O5
Molecular Weight
364.7803
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3- (ethoxycarbonyl) -, ethyl ester
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