4EGI-1
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E) ; disrupts eIF4E/eIF4G association and inhibits cap-dependent translation; inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.
Product Specifications
CAS Number
315706-13-9
Product Name Alternative
EIF4E/eIF4G Interaction Inhibitor
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
O=C (O) /C (CC1=CC=CC=C1[N+] ([O-]) =O) =N/NC2=NC (C3=CC=C (Cl) C (Cl) =C3) =CS2
Molecular Formula
C18H12Cl2N4O4S
Molecular Weight
451.2833
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenepropanoic acid, α-[2-[4- (3,4-dichlorophenyl) -2-thiazolyl]hydrazinylidene]-2-nitro-
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