Azathioprine
Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. (In Vitro) :Azathioprine (0-50 μM, 48 hours) can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes. (In Vivo) :Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice.
Product Specifications
CAS Number
446-86-6
Product Name Alternative
Azamune | Azoran | BW 57-322 | Imuran | NSC 39084
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 54 mg/mL (194.76 mM)
Smiles
O=[N+] (C1=C (SC2=C3NC=NC3=NC=N2) N (C) C=N1) [O-]
Molecular Formula
C9H7N7O2S
Molecular Weight
277.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- ((1-methyl-4-nitro-1H-imidazol-5-yl) thio) -7H-purine
Available Sizes
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