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PRIMA-1

A specific mutant p53 reactivator that induces apoptosis and enhances chemotherapeutic cytotoxicity in cancer cell lines; is efficacious against myeloma cells with differential p53 genotypes, causes the demethylation of TP73, through DNMT1 depletion, to subsequently enhance UPR; selectively induces apoptosis and cell cycle arrest in p53 mutant cells compared to CAPAN-2 cells.Blood Cancer Phase 2 Clinical.

Product Specifications

CAS Number

5608-24-2

Product Name Alternative

PRIMA 1 | PRIMA1

Field of Research

Neuroscience

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 44 mg/mL

Smiles

O=C1C (CO) (CO) N2CCC1CC2

Molecular Formula

C9H15NO3

Molecular Weight

185.2203

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis (hydroxymethyl) -

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