GW788388
A potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay; displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.) ; has an IC50 of 93 nM in TGF-β cellular assay; presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.
Product Specifications
CAS Number
452342-67-5
Product Name Alternative
GW 788388 | GW-788388
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 48 mg/mL
Smiles
O=C (NC1CCOCC1) C2=CC=C (C3=NC=CC (C4=CNN=C4C5=NC=CC=C5) =C3) C=C2
Molecular Formula
C25H23N5O2
Molecular Weight
425.4824
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 4-[4-[3- (2-pyridinyl) -1H-pyrazol-4-yl]-2-pyridinyl]-N- (tetrahydro-2H-pyran-4-yl) -
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