GW788388
A potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay; displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.) ; has an IC50 of 93 nM in TGF-β cellular assay; presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.
Product Specifications
CAS Number
452342-67-5
Product Name Alternative
GW 788388 | GW-788388
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 48 mg/mL
Smiles
O=C (NC1CCOCC1) C2=CC=C (C3=NC=CC (C4=CNN=C4C5=NC=CC=C5) =C3) C=C2
Molecular Formula
C25H23N5O2
Molecular Weight
425.4824
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 4-[4-[3- (2-pyridinyl) -1H-pyrazol-4-yl]-2-pyridinyl]-N- (tetrahydro-2H-pyran-4-yl) -
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
26300121 3x 1.0µg DNA
LAPTM4A CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details MBS659499-01 1 mg
Vasoactive Intestinal Peptide (VIP) (6-28) (human, bovine, porcine, rat)
Sign In for Pricing
View Details MBS659499-02 5x 1 mg
Vasoactive Intestinal Peptide (VIP) (6-28) (human, bovine, porcine, rat)
Sign In for Pricing
View Details