OSU-03012
OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM; decreases incidences of carcinoma and metastasis in transgenic mouse model of prostate cancer.Blood Cancer Phase 1 Clinical.
Product Specifications
CAS Number
742112-33-0
Product Name Alternative
AR-12 | AR 12 | OSU 03012
Purity
>98% (HPLC)
Solubility
DMSO: 9 mg/mL (19.5 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
NCC (=O) NC1=CC=C (C=C1) N1N=C (C=C1C1=CC2=C (C=C1) C1=CC=CC=C1C=C2) C (F) (F) F
Molecular Formula
C26H19F3N4O
Molecular Weight
460.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-amino-N-{4-[5- (2-phenanthrenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]-phenyl} acetamide
Available Sizes
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