JNJ-17203212
A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively; exhibits high selectivity against a panel of receptors and transporters, and does not inhibits related TRP channels TRPV2, TRPV4, or TRPA1; inhibits both pH (pIC50=7.23) and capsaicin (pIC50=6.32) -induced channel activation; attenuates capsaicin evoked coughs, prevents core hypothermia evoked by capsaicin in vivo.Pain Preclinical.
Product Specifications
CAS Number
821768-06-3
Product Name Alternative
JNJ17203212 | JNJ 17203212
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1CCN (C2=NC=CC=C2C (F) (F) F) CC1) NC3=NC=C (C (F) (F) F) C=C3
Molecular Formula
C17H15F6N5O
Molecular Weight
419.3243
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperazinecarboxamide, 4-[3- (trifluoromethyl) -2-pyridinyl]-N-[5- (trifluoromethyl) -2-pyridinyl]-
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