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AIM-100

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN; inhibits Ack1 Tyr284-phosphorylation attenuated pTyr267-AR transcriptional activity which in turn resulted in cell cycle arrest; inhibits pTyr284 -Ack1 expression, and prostate cancer cell proliferation.

Product Specifications

CAS Number

873305-35-2

Product Name Alternative

AIM 100 | AIM100

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

C12=NC=NC (NC[C@H]3OCCC3) =C1C (C4=CC=CC=C4) =C (C5=CC=CC=C5) O2

Molecular Formula

C23H21N3O2

Molecular Weight

371.44

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[ (2S) -tetrahydro-2-furanyl]methyl]-

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