BMH-21

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription; inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins; causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit) ; activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.