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A 83-01

A potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively; dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3; prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.

Product Specifications

CAS Number

909910-43-6

Product Name Alternative

A83-01 | A-83-01

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

S=C (N1N=C (C2=NC (C) =CC=C2) C (C3=CC=NC4=CC=CC=C34) =C1) NC5=CC=CC=C5

Molecular Formula

C25H19N5S

Molecular Weight

421.5168

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1H-Pyrazole-1-carbothioamide, 3- (6-methyl-2-pyridinyl) -N-phenyl-4- (4-quinolinyl) -

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