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Ulixertinib

Ulixertinib (BVD-523) is a potent and reversible dual inhibitor of ERK1 and ERK2, exhibiting an IC50 below 0.3 nM for ERK2. It is widely used in preclinical cancer research to investigate MAPK pathway signaling in both cellular and animal models of various malignancies.

Product Specifications

CAS Number

869886-67-9

Product Name Alternative

Ulixertinib, VRT 752271, VRT752271, VRT-752271, Inhibitor, Extracellular signal regulated kinases, ERK, ERK2, inhibit, BVD 523, BVD523, BVD-523

Field of Research

Signal Transduction

Purity

99.31% (May vary between batches)

Solubility

Ethanol:12 mg/mL (27.69 mM) ; DMSO:250 mg/mL (576.93 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (18.46 mM)

Smiles

CC (C) Nc1cc (-c2c[nH]c (c2) C (=O) N[C@H] (CO) c2cccc (Cl) c2) c (Cl) cn1

Molecular Formula

C21H22Cl2N4O2

Molecular Weight

433.33

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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