Tris (3-hydroxypropyltriazolylmethyl) amine

Tris (3-hydroxypropyltriazolylmethyl) amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris (3-hydroxypropyltriazolylmethyl) amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration[1][2][3][4][5].

Product Specifications

CAS Number

[760952-88-3]

Product Name Alternative

THPTA

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tris-3-hydroxypropyltriazolylmethyl-amine.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 175 mg/mL

Smiles

OCCCN1N=NC(CN(CC2=CN(CCCO)N=N2)CC3=CN(CCCO)N=N3)=C1

Molecular Formula

C18H30N10O3

Molecular Weight

434.50

Precautions

H315, H319, H335

References & Citations

[1]Hong V, et al. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl. 2009;48 (52) :9879-83.|[2]Hong V, et al. Labeling live cells by copper-catalyzed alkyne− azide click chemistry. Bioconjugate chemistry 21.10 (2010) : 1912-1916.|[3]Rathinam S, et al. Conjugation of CRAMP18-35 Peptide to Chitosan and Hydroxypropyl Chitosan via Copper-Catalyzed Azide-Alkyne Cycloaddition and Investigation of Antibacterial Activity. Int J Mol Sci. 2024 Aug 30;25 (17) :9440.|[4]Yuan Y, et al. Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation. Angew Chem Int Ed Engl. 2016 May 23;55 (22) :6457-61.|[5]Kozarski M, et al. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs. RSC Adv. 2023 Apr 25;13 (19) :12809-12824.