GNE-493
A potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR; displays 100-fold selective for PI3Kα over Aurora A, MLK1, Syk; has good PK profiles, and are efficacious in xenograft models; orally available.
Product Specifications
CAS Number
1033735-94-2
Product Name Alternative
GNE493 | GNE 493
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 45 mg/mL
Smiles
CC (O) (C1=CC2=NC (C3=CN=C (N) N=C3) =NC (N4CCOCC4) =C2S1) C
Molecular Formula
C17H20N6O2S
Molecular Weight
372.4447
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Thieno[3,2-d]pyrimidine-6-methanol, 2- (2-amino-5-pyrimidinyl) -α, α-dimethyl-4- (4-morpholinyl) -
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