Bicyclol
Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Bicyclol promotes toll-like 2 receptor recruiting inosine 5'-monophosphate dehydrogenase II to exert its anti-inflammatory effect.
Product Specifications
CAS Number
118159-48-1
Product Name Alternative
Bicyclol | SY 801 | SY-801 | SY801
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 68 mg/mL. 174.21 mM
Smiles
COc1c2c (c (c (c1) CO) c1c3c (c (cc1C (=O) OC) OC) OCO3) OCO2
Molecular Formula
C19H18O9
Molecular Weight
390.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5'- (hydroxymethyl) -7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester
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