ALW-II-41-27
ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors.
Product Specifications
CAS Number
1186206-79-0
Product Name Alternative
ALW-II-41-27 | ALW II-41-27 | ALWII-41-27
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 47 mg/mL. 77.34 mM
Smiles
CC1=C (NC (C2=CC (C3=CC=CS3) =CN=C2) =O) C=C (C (NC4=CC=C (CN5CCN (CC) CC5) C (C (F) (F) F) =C4) =O) C=C1
Molecular Formula
C32H32F3N5O2S
Molecular Weight
607.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (5- ((4- ((4-ethylpiperazin-1-yl) methyl) -3- (trifluoromethyl) phenyl) carbamoyl) -2-methylphenyl) -5- (thiophen-2-yl) nicotinamide
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