APY29
APY29 is a IRE1α inhibitor. The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR) . ATP-competitive inhibitors of IRE1α promote dimerization and activation of RNase activity despite blocking kinase autophosphorylation.
Product Specifications
CAS Number
1216665-49-4
Product Name Alternative
APY29 | APY-29 | APY 29
Purity
>98% (HPLC)
Solubility
DMSO : 10 mg/mL. 30.09 mM
Smiles
C1CC1c1cc (n[nH]1) Nc1nc (ncc1) Nc1cc2c (cc1) nc[nH]2
Molecular Formula
C17H16N8
Molecular Weight
332.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -N- (6- ((5-cyclopropyl-1H-pyrazol-3-yl) imino) -1,6-dihydropyrimidin-2-yl) -1H-benzo[d]imidazol-6-amine
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