E6446
E6446 inhibits Toll-like receptor (TLR) 7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG) -containing DNA, which stimulates TLR9.
Product Specifications
CAS Number
1219925-73-1
Product Name Alternative
E6446 | E 6446 | E-6446
Purity
>98% (HPLC)
Smiles
C1CCN (C1) CCCOc1ccc (cc1) c1nc2c (o1) cc (cc2) OCCCN1CCCC1
Molecular Formula
C27H35N3O3
Molecular Weight
449.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (3-Pyrrolidin-1-yl-propoxy) -2-[4- (3-pyrrolidin-1-yl-propoxy) -phenyl]-benzooxazole
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