ADX88178
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.
Product Specifications
CAS Number
1235318-89-4
Product Name Alternative
ADX-88178 | ADX 88178 | ADX88178
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL 183.60 mM
Smiles
Cc1nc (Nc2nc (c3c[nH]nc3) c (C) s2) ncc1
Molecular Formula
C12H12N6S
Molecular Weight
272.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-methyl-N- (4-methylpyrimidin-2-yl) -4- (1H-pyrazol-4-yl) thiazol-2-amine
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