QNZ46
QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.
Product Specifications
CAS Number
1237744-13-6
Product Name Alternative
QNZ46 | QNZ-46 | QNZ 46
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 4.5 mg/mL10.15 mM
Smiles
COc1cc2c (cc1) nc (n (c2=O) c1ccc (cc1) C (=O) O) /C=C/c1cc (ccc1) [N+] (=O) [O-]
Molecular Formula
C24H17N3O6
Molecular Weight
443.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -4- (6-methoxy-2- (3-nitrostyryl) -4-oxoquinazolin-3 (4H) -yl) benzoic acid
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