XL388
XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR) . XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473) ) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.
Product Specifications
CAS Number
1251156-08-7
Product Name Alternative
XL388 | XL-388 | XL 388
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 109.77 mM
Smiles
Cc1c (ccc (c1F) S (=O) (=O) C) C (=O) N1CCOc2c (C1) cc (cc2) c1cnc (cc1) N
Molecular Formula
C23H22FN3O4S
Molecular Weight
455.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(7- (6-aminopyridin-3-yl) -2,3-dihydrobenzo[f][1,4]oxazepin-4 (5H) -yl) (3-fluoro-2-methyl-4- (methylsulfonyl) phenyl) methanone
Available Sizes
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