CNX-1351
CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20 400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
Product Specifications
CAS Number
1276105-89-5
Product Name Alternative
CNX1351 | CNX 1351 | CNX-1351
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 21.8 mg/mL. 38.00 mM
Smiles
C1CN (CCN1C (=O) CCC (=O) C=C (C) C) Cc1cc2c (s1) c (nc (n2) c1cccc2c1cn[nH]2) N1CCOCC1
Molecular Formula
C30H35N7O3S
Molecular Weight
573.71
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (4- ((2- (1H-indazol-4-yl) -4-morpholinothieno[3,2-d]pyrimidin-6-yl) methyl) piperazin-1-yl) -6-methylhept-5-ene-1,4-dione
Available Sizes
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