BPR1J-097
BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. BPR1J-097 may be useful in AML treatments.IC50 of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC (50) s) were 21 ±7 and 46 ±14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.
Product Specifications
CAS Number
1327167-19-0
Product Name Alternative
BPR1J097 | BPR1J-097 | BPR1J 097
Purity
>98% (HPLC)
Smiles
CN1CCN (CC1) c1ccc (cc1) C (=O) Nc1n[nH]c (c1) c1cc (ccc1) NS (=O) (=O) c1ccccc1
Molecular Formula
C27H28N6O3S
Molecular Weight
516.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (4-methylpiperazin-1-yl) -N- (3- (3- (phenylsulfonamido) phenyl) -1H-pyrazol-5-yl) benzamide.
Available Sizes
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