BI-4464

BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 is a FAK (HY-43760) ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467) . PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader[1][2][3].

Product Specifications

CAS Number

[1227948-02-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

FAK; Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bi-4464.html

Purity

98.64

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(OC4=CC=CC(CC5)=C4C5=O)=N3)C(OC)=C2

Molecular Formula

C28H28F3N5O4

Molecular Weight

555.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62 (5) :2508-2520.|[2]Moni BM, et al. Ebola Virus GP Activates Endothelial Cells via Host Cytoskeletal Signaling Factors. Viruses. 2022 Jan 13;14 (1) :142. |[3]Liu C, et al. Structure-guided design of a potent focal adhesion kinase (FAK) degrader via ternary complex modeling and molecular dynamics simulation. Bioorg Chem. 2025 Oct;165:109017.