LDC1267
LDC1267 is a potent and selective TAM kinase inhibitor. LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8. LDC1267 markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b. Treatment of wild-type NK cells with a newly developed small molecule TAM kinase inhibitor conferred therapeutic potential, efficiently enhancing anti-metastatic NK cell activity in vivo.
Product Specifications
CAS Number
1361030-48-9
Product Name Alternative
LDC1267 | LDC-1267 | LDC 1267
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 89.20 mM; H2O : < 0.1 mg/mL
Smiles
C1 (c (cc2c (c1) c (ccn2) Oc1ccc (cc1F) NC (=O) c1nn (cc1OCC) c1ccc (cc1C) F) OC) OC
Molecular Formula
C30H26F2N4O5
Molecular Weight
560.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[4-[ (6,7-dimethoxy-4-quinolyl) oxy]-3-fluoro-phenyl]-4-ethoxy-1- (4-fluoro-2-methyl-phenyl) pyrazole-3-carboxamide
Available Sizes
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Nkx2-5 (Homeobox Protein Nkx-25, Cardiac-specific Homeobox, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e) (MaxLight 550)
Nkx2-5 (Homeobox Protein Nkx-25, Cardiac-specific Homeobox, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e) (MaxLight 550)