CEP37440
CEP-37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors.
Product Specifications
CAS Number
1391712-60-9
Product Name Alternative
CEP37440 | CEP 37440 | CEP-37440
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 41 mg/mL. 70.68 mM
Smiles
CNC (=O) c1ccccc1Nc1nc (ncc1Cl) Nc1c (c2c (C[C@H] (CCC2) N2CCN (CC2) CCO) cc1) OC
Molecular Formula
C30H38ClN7O3
Molecular Weight
580.12
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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