ML281
ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM) . ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.
Product Specifications
CAS Number
1404437-62-2
Product Name Alternative
ML-281 | ML-281 | ML281
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL. 77.03 mM; H2O : < 0.1 mg/mL
Smiles
O=C (c1cccs1) Nc1ccc (C (C) C) cc1c1nc2c (cccc2) [nH]c1=O
Molecular Formula
C22H19N3O2S
Molecular Weight
389.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[2- (3,4-Dihydro-3-oxo-2-quinoxalinyl) -4- (1-methylethyl) phenyl]-2-thiophenecarboxamide
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