TG6-10-1
TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely. TG6-10-1 shows low-nanomolar antagonist activity against EP2.
Product Specifications
CAS Number
1415716-58-3
Product Name Alternative
TG6-10-1 | TG 6-10-1 | TG-6-10-1 | TP6101
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 223.00 mM
Smiles
C (=O) (/C=C/c1cc (c (c (c1) OC) OC) OC) NCCn1c (cc2ccccc12) C (F) (F) F
Molecular Formula
C23H23F3N2O4
Molecular Weight
448.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3,4,5-trimethoxyphenyl) acrylamide
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