UNC-2025
UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
Product Specifications
CAS Number
1429881-91-3
Product Name Alternative
UNC2025, UNC2025, UNC 2025
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL. 69.92 mM
Smiles
CCCCNc1ncc2c (cn (c2n1) [C@H]1CC[C@@H] (CC1) O) c1ccc (cc1) CN1CCN (CC1) C.Cl.Cl
Molecular Formula
C28H41ClN6O
Molecular Weight
513.12
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1r,4r) -4- (2- (butylamino) -5- (4- ((4-methylpiperazin-1-yl) methyl) phenyl) -7H-pyrrolo[2,3-d]pyrimidin-7-yl) cyclohexanol
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