CPI-169
CPI-169 is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) with an IC50 value of <1nM for polycomb repressive complex 2 (PRC2) . CPI-169 was shown to inhibit tumor growth in a NHL xenograft model, reducing global H3K27me3.1 It has also been shown to synergize with the B-cell lymphoma inhibitor, ABT-199, to suppress the growth of NHL cell lines.
Product Specifications
CAS Number
1450655-76-1
Product Name Alternative
CPI-169 | CPI 169 | CPI169
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 59 mg/mL. 111.60 mM
Smiles
CCS (=O) (=O) N1CCC (CC1) C (C) n1c2ccccc2c (C (=O) NCc2c (OC) cc (C) [nH]c2=O) c1C
Molecular Formula
C27H36N4O5S
Molecular Weight
528.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R, Z) -1- (1- (1- (ethylsulfonyl) piperidin-4-yl) ethyl) -N- ((2-hydroxy-4-methoxy-6-methylpyridin-3-yl) methyl) -2-methyl-1H-indole-3-carbimidic acid
Available Sizes
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