Cambinol
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.
Product Specifications
CAS Number
14513-15-6
Product Name Alternative
SIRT 1/2 inhibitor IV | NSC112546 | NSC-112546
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL. 138.72 mM; H2O : < 0.1 mg/mL
Smiles
O=c1c (Cc2c3ccccc3ccc2O) c (c2ccccc2) [nH]c (=S) [nH]1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.09
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- ((2-hydroxynaphthalen-1-yl) methyl) -6-phenyl-2-thioxo-2,3-dihydropyrimidin-4 (1H) -one
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