UNC2881
UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
Product Specifications
CAS Number
1493764-08-1
Product Name Alternative
UNC2881, UNC-2881, UNC 2881
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 44 mg/mL; 94.91 mM
Smiles
CCCCNc1ncc (c (N[C@@H]2CC[C@H] (CC2) O) n1) C (=O) NCc1ccc (n2ccnc2) cc1
Molecular Formula
C25H33N7O2
Molecular Weight
463.58
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (1H-imidazol-1-yl) benzyl) -2- (butylamino) -4- (((1r,4r) -4-hydroxycyclohexyl) amino) pyrimidine-5-carboxamide
Available Sizes
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