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DprE1-IN-1

TBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1) with an IC50 value of 10 nM. It also inhibits PDE6 with an IC50 value of 4 μM.1 AZ 7371 has been shown to be active against M. tuberculosis with an MIC range of 0.78-3.12 μM and demonstrates efficacy in a rodent model of tuberculosis.

Product Specifications

CAS Number

1494675-86-3

Product Name Alternative

TBA-7371 | TBA 7371 | TBA7371

Purity

>98% (HPLC)

Solubility

DMSO : 11 mg/mL. 30.95 mM

Smiles

Cc1cc2c (c (cn2Cc2c (c (ncn2) OC) C) C (=O) NCCO) nc1

Molecular Formula

C18H21N5O3

Molecular Weight

355.39

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

N- (2-hydroxyethyl) -1- ((6-methoxy-5-methylpyrimidin-4-yl) methyl) -6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

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