XEN-445
XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
Product Specifications
CAS Number
1515856-92-4
Product Name Alternative
XEN445 | XEN 445 | XEN-445
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 40 mg/mL. 109.19 mM
Smiles
C1 (ccc (c (c1) C (=O) O) N1C[C@H] (CC1) OCc1ncccc1) C (F) (F) F
Molecular Formula
C18H17F3N2O3
Molecular Weight
366.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -2- (3- (pyridin-2-ylmethoxy) pyrrolidin-1-yl) -5- (trifluoromethyl) benzoic acid
Available Sizes
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