AZ191
AZ191 is a novel, potent and selective DYRK1B inhibitor. AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr (286), not Thr (288) . AZ191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene. AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.
Product Specifications
CAS Number
1594092-37-1
Product Name Alternative
AZ191 | AZ-191 | AZ 191
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL. 69.85 mM; H2O : < 0.1 mg/mL
Smiles
CN1CCN (CC1) c1cc (c (cc1) Nc1nccc (n1) c1cn (c2c1ccnc2) C) OC
Molecular Formula
C24H27N7O
Molecular Weight
429.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (2-methoxy-4- (4-methylpiperazin-1-yl) phenyl) -4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl) pyrimidin-2-amine
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