FIIN-3
FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R.
Product Specifications
CAS Number
1637735-84-2
Product Name Alternative
FIIN3 | FIIN 3 | FIIN-3
Purity
>98% (HPLC)
Solubility
DMSO : 10 mg/mL 14.46 mM
Smiles
C (=O) (C=C) Nc1ccc (cc1) CN (c1ncnc (c1) Nc1ccc (cc1) N1CCN (CC1) C) C (=O) Nc1c (c (cc (c1Cl) OC) OC) Cl
Molecular Formula
C34H36Cl2N8O4
Molecular Weight
691.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- ((3- (2,6-dichloro-3,5-dimethoxyphenyl) -1- (6- ((4- (4-methylpiperazin-1-yl) phenyl) amino) pyrimidin-4-yl) ureido) methyl) phenyl) acrylamide
Available Sizes
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