BChE-IN-33
Product Specifications
UNSPSC Description
BChE-IN-33 (compound 4r), an arylaminonaphthol derivative, is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 of 14.78 µM. BChE-IN-33 also inhibits CYP2C19, CYP2C9, CYP2D6. BChE-IN-33 shows potent antioxidant activity with IC50 values of 150.48 μM, 2.56 μM and 4.61 μM by DPPH, ABTS, Ferric-phenanthroline assay, respectively. BChE-IN-33 has the potential for Alzheimer research[1].
Target Antigen
Cholinesterase (ChE); Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-in-33.html
Smiles
OC1=CC=C2C=CC=CC2=C1C(NC3=CC=C(Cl)C=C3)C4=CC=CC([N+]([O-])=O)=C4
Molecular Weight
404.85
References & Citations
[1]Racha Amira Benoune, et al. Synthesis, biological evaluation, theoretical calculations, QSAR and molecular docking studies of novel arylaminonaphthols as potent antioxidants and BChE inhibitors. Bioorg Chem. 2024 Sep:150:107598.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159143/BChE-IN-33-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159143/
Clinical Information
No Development Reported
Curated Selection
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