BChE-IN-33

BChE-IN-33 (compound 4r), an arylaminonaphthol derivative, is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 of 14.78 µM. BChE-IN-33 also inhibits CYP2C19, CYP2C9, CYP2D6. BChE-IN-33 shows potent antioxidant activity with IC50 values of 150.48 μM, 2.56 μM and 4.61 μM by DPPH, ABTS, Ferric-phenanthroline assay, respectively. BChE-IN-33 has the potential for Alzheimer research[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-in-33.html

Smiles

OC1=CC=C2C=CC=CC2=C1C(NC3=CC=C(Cl)C=C3)C4=CC=CC([N+]([O-])=O)=C4

Molecular Formula

C23H17ClN2O3

Molecular Weight

404.85

References & Citations

[1]Racha Amira Benoune, et al. Synthesis, biological evaluation, theoretical calculations, QSAR and molecular docking studies of novel arylaminonaphthols as potent antioxidants and BChE inhibitors. Bioorg Chem. 2024 Sep:150:107598.