Su1498
SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Product Specifications
CAS Number
168835-82-3
Product Name Alternative
SU-1498 | SU 1498 | SU1498 | Tyrphostin SU 1498
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 150 mg/mL. 384.10 mM
Smiles
O=C (/C (=C/c1cc (C (C) C) c (O) c (C (C) C) c1) /C#N) NCCCc1ccccc1
Molecular Formula
C25H30N2O2
Molecular Weight
390.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2E) -2-cyano-3-[4-hydroxy-3,5-bis (1-methylethyl) phenyl]-N- (3-phenylpropyl) -2-propenamide
Available Sizes
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NOLC1 (KIAA0035, Nucleolar and Coiled-Body Phosphoprotein 1, Nucleolar Phosphoprotein p130, Nucleolar 130kD Protein, 140kD Nucleolar Phosphoprotein, Nopp140, Hepatitis C Virus NS5A-Transactivated Protein 13, HCV NS5A-Transactivated Protein 13, NS5ATP13) (
RFXANK (DNA-binding Protein RFXANK, Ankyrin Repeat Family A Protein 1, Regulatory Factor X Subunit B, RFX-B, Regulatory Factor X-associated Ankyrin-containing Protein, ANKRA1, RFXB, F14150_1, MGC138628) (MaxLight 650)
RFXANK (DNA-binding Protein RFXANK, Ankyrin Repeat Family A Protein 1, Regulatory Factor X Subunit B, RFX-B, Regulatory Factor X-associated Ankyrin-containing Protein, ANKRA1, RFXB, F14150_1, MGC138628) (MaxLight 650)