RO 46-8443
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.
Product Specifications
CAS Number
175556-12-4
Product Name Alternative
RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (410.04 mM)
Smiles
C1 (ccc (cc1) C (C) (C) C) S (=O) (=O) Nc1nc (nc (c1Oc1c (cccc1) OC) OC[C@@H] (CO) O) c1ccc (cc1) OC
Molecular Formula
C31H35N3O8S
Molecular Weight
609.69
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (tert-butyl) -N- (6- (2,3-dihydroxypropoxy) -5- (2-methoxyphenoxy) -2- (4-methoxyphenyl) pyrimidin-4-yl) benzenesulfonamide
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