SGC2085 HCl
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
Product Specifications
CAS Number
1821908-49-9
Purity
>98% (HPLC)
Smiles
C (=O) ([C@H] (C) N) NCc1cc (c (cc1) Oc1cc (cc (c1) C) C) C.Cl
Molecular Formula
C19H24N2O2·HCl
Molecular Weight
348.87
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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