PD0166285
PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line.
Product Specifications
CAS Number
185039-89-8
Product Name Alternative
PD0166285 | PD 0166285 | PD0166285
Purity
>98% (HPLC)
Solubility
DMSO : 65 mg/mL 126.85 mM; H2O : < 0.1 mg/mL
Smiles
CCN (CC) CCOc1ccc (Nc2nc3c (cn2) cc (c (=O) n3C) c2c (Cl) cccc2Cl) cc1
Molecular Formula
C26H27Cl2N5O2
Molecular Weight
512.43
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (2,6-dichlorophenyl) -2- ((4- (2- (diethylamino) ethoxy) phenyl) amino) -8-methylpyrido[2,3-d]pyrimidin-7 (8H) -one
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