Pardoprunox hydrochloride
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. (In Vitro) :Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [ (35) S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [ (35) S]GTPgammaS binding (pA2=9.0) . Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3) .
Product Specifications
CAS Number
269718-83-4
Product Name Alternative
SLV-308 hydrochloride | DU-126891 hydrochloride
Purity
>98% (HPLC)
Solubility
H2O : < 0.1 mg/mL
Smiles
O=c1oc2c (N3CCN (C) CC3) cccc2[nH]1.Cl.Cl
Molecular Formula
C12H16ClN3O2
Molecular Weight
269.73
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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